Our Scientists


Colette T. Dooley

Assistant Member

Dr. Colette Dooley completed her undergraduate studies with honors in 1987 and earned her Masters of Science degree in Zoology ("Identification of binding sites for Atrial Natriuretic Peptide on Gills of Salmonids"), both at the University College Dublin, Ireland. She joined the Torrey Pines Institute in 1990 as a Research Assistant and her research included developing high throughput radioreceptor screening assays and modifying existing opioid receptor assays for screening with combinatorial libraries. In 1994, she was named a Assistant Member at TPIMS and supervised five research technicians on projects involving the use of mixture based combinatorial libraries in radioreceptor assays for opioid ligands, melanocortin ligands, melanin concentrating hormone, substance P and orphanin FQ and is now the lead author of a study on compounds that are in clinical trials.


CHRISTOPHER ARMISHAW

Assistant Member

Dr. Armishaw completed his undergraduate studies in Chemistry with honors in 1998 from the University of Melbourne, Australia, and his Ph.D. in Chemistry at the Institute for Molecular Bioscience within the University of Queensland, Australia, ("Controlling Cysteine Frameworks in Structurally Constrained Conotoxins") in 2003. Dr. Armishaw received the University of Queensland Graduate School Research Travel Award in 2001 and with the award, he spent a summer at the Scripps Research Institute in San Diego, CA. He also was awarded the Royal Australian Chemical Society / Bionomics award for the best Ph.D. thesis in biomolecular studies after completing his Ph.D. He then joined the University of Queensland as a post doctoral Research Officer under Professor Paul Alewood. For two years, Dr. Armishaw undertook post doctoral research at the Faculty of Pharmaceutical Sciences at the University of Copenhagen, Denmark with Professor Kristian Strømgaard. Dr. Armishaw has 11 publications and has contributed to one patent involving cyclised conotoxin peptides. His professional affiliations include the Royal Australian Chemical Institute and the American Peptide Society. Dr. Armishaw joined the Torrey Pines Institute in February 2008 as an Assistant Member.


ADEL NEFZI

Assistant Member

Combinatorial chemistry initially involved the synthesis of very large libraries of biological oligomers such as peptides, peptidomimetics and oligonucleotides. Such oligomers, while valuable in their own right, have limitations as pharmaceutical agents and are susceptible to rapid enzymatic degradation. The focus of combinatorial chemistry has shifted in recent years to libraries of small acyclic and heterocyclic molecules having molecular weights of 500 dalton or less, due to their proven utility as therapeutic agents. The goal of our group is the design and synthesis of organic acyclic and heterocyclic compounds on solid supports, and the synthesis of subsequent combinatorial libraries.